Previously in this series, we've discussed the role of cellular energy excess, inflammation, brain insulin resistance, and micronutrient status in insulin resistance. In this post, I'll explore the role of macronutrients and sugar in insulin sensitivity.
Carbohydrate and Fat
There are a number of studies on the effect of carbohydrate:fat ratios on insulin sensitivity, but many of them are confounded by fat loss (e.g., low-carbohydrate and low-fat weight loss studies), which almost invariably improves insulin sensitivity. What interests me the most is to understand what effect different carbohydrate:fat ratios have on insulin sensitivity in healthy, weight stable people. This will get at what causes insulin resistance in someone who does not already have it.
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Showing posts with label low-carb. Show all posts
Showing posts with label low-carb. Show all posts
Sunday, January 15, 2012
Monday, August 15, 2011
I Got Boinged, and Other News
The reaction to my post "The Carbohydrate Hypothesis of Obesity: a Critical Examination" has been overwhelmingly positive, particularly among the scientists I've heard from.
On Saturday, the inimitable maker and writer Mark Frauenfelder posted a link to my post on the variety blog BoingBoing. BoingBoing has been on my sidebar for three years, and it's the place I go when I need a break. It's a fun assortment of science, news, technology and entertainment. BoingBoing was originally a zine started by Frauenfelder and his wife in 1988, and it has been on the web since 1995. Today, it has multiple contributing authors and it draws several hundred thousand hits per day. I'm thrilled that Frauenfelder posted my article there. Apparently he likes my blog. Thanks!
I added a new section (IIB) to my original post. It discusses what human genetics can teach us about the mechanisms of common obesity. It is consistent with the rest of the evidence suggesting that body fatness is primarily regulated by the brain, not by fat tissue, and that leptin signaling plays a dominant role in this process.
On Saturday, the inimitable maker and writer Mark Frauenfelder posted a link to my post on the variety blog BoingBoing. BoingBoing has been on my sidebar for three years, and it's the place I go when I need a break. It's a fun assortment of science, news, technology and entertainment. BoingBoing was originally a zine started by Frauenfelder and his wife in 1988, and it has been on the web since 1995. Today, it has multiple contributing authors and it draws several hundred thousand hits per day. I'm thrilled that Frauenfelder posted my article there. Apparently he likes my blog. Thanks!
I added a new section (IIB) to my original post. It discusses what human genetics can teach us about the mechanisms of common obesity. It is consistent with the rest of the evidence suggesting that body fatness is primarily regulated by the brain, not by fat tissue, and that leptin signaling plays a dominant role in this process.
Thursday, August 11, 2011
The Carbohydrate Hypothesis of Obesity: a Critical Examination
Introduction
I'd like to begin by emphasizing that carbohydrate restriction has helped many people lose body fat and improve their metabolic health. Although it doesn't work for everyone, there is no doubt that carbohydrate restriction causes fat loss in many, perhaps even most obese people. For a subset of people, the results can be very impressive. I consider that to be a fact at this point, but that's not what I'll be discussing here.
What I want to discuss is a hypothesis. It's the idea, championed by Gary Taubes, that carbohydrate (particularly refined carbohydrate) causes obesity by elevating insulin, thereby causing increased fat storage in fat cells. To demonstrate that I'm representing this hypothesis accurately, here is a quote from his book Good Calories, Bad Calories:
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I'd like to begin by emphasizing that carbohydrate restriction has helped many people lose body fat and improve their metabolic health. Although it doesn't work for everyone, there is no doubt that carbohydrate restriction causes fat loss in many, perhaps even most obese people. For a subset of people, the results can be very impressive. I consider that to be a fact at this point, but that's not what I'll be discussing here.
What I want to discuss is a hypothesis. It's the idea, championed by Gary Taubes, that carbohydrate (particularly refined carbohydrate) causes obesity by elevating insulin, thereby causing increased fat storage in fat cells. To demonstrate that I'm representing this hypothesis accurately, here is a quote from his book Good Calories, Bad Calories:
Read more »
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